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The PlA1/PlA2 polymorphism lies in the gene with the βthree (GPIIIa) subunit of αIIbβthree (GPIIb-IIIa). This integrin serves to be a receptor for adhesive proteins fibrinogen and von Willebrand element which is essential with the cohesive properties of platelets. Recognition of these proteins as soluble ligands requires αIIbβthree to generall

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